Powering Up My Healthy Genes
What genes do I want to power up and what genes do I want to turn off? This is a great question that I am asked frequently. The human genome has 23,000 genes that influence 40-60 trillion cells of the body. The more precise question is, is it possible to program my genes favorably? Yes! Contrary to popular thinking, the current medical view of prevention of bad expressed genes like BRCA, is to use the scalpel to remove the breasts of women that express positively. What many people are not aware of is BRCA expresses on other types of cancers that involve major organs. These organs cannot be surgically removed as the only remedy as they are critical to survival. Surely, we must do better than this with all of the intelligence of genetics and epigenetics. Yet, institutionalized medicine continues to inform us that personalized medicine is simply a better genetic matching of target specific drugs and better ways of matching chemotherapy, radiation and surgery. Powering up healthy genes has nothing to do with focusing on conventional modalities of intervention and false notions of prevention. Powering up healthy genes involves revealing the vulnerabilities and addressing the root causes of aggravations that initiate unhealthy signals and changing them. Minimizing the value of personalized diagnostics of genetics and epigenetics is not the focus, focusing in upon the personalized applications that inhibit the accelerated aging process, inhibiting the negative expressions resulting in mutations that cause serious disease and enhancing the expressed health and survival of healthy human cells and their vital function is where the personalized value is.
The field of epigenetics is a powerful life-changing field. The human genome is an unchangeable architecture. Simply, humans inherit certain characteristics that either influence both favorable and unfavorable adaptive capabilities. I describe these characteristics as gene “sensitivities” rather than risk. I promote the term “sensitivities” as it is a great descriptive of empowerment rather than a succumbing negative defeating finality. Epigenetics is simply a science of programming and such programming could contain accelerated enhancing or correcting value or unfavorable glitches.
Epigenetics can be used positively in personalized health and medicine to design more intelligent strategies to encourage favorable improvements regarding gene expressions. Currently, westernized medicine (institutionalized) focuses in upon the diagnostic and risk values rather than the personalized applications. It is crucial to know that dynamic alterations affecting the sequencing of DNA within the cell can initiate either protective or damaging action. DNA methylation is an example of such a process. In other articles we have discussed methylation and the need to protect healthy DNA sequencing. Intelligent programming of individualized epigenetic signals makes sense and I will be discussing particulars below. See link: https://www.healthcoach7.com//epigenetics-and-cancer-causing-genes-oncogenes/
Functional and Integrative Dynamics
HealthCoach7 analyzes gene / snp variations according to health function relationships. There are six functional dynamics namely genes, metabolism (methylation), immunity, inflammation, detoxification and hormones (endocrine and neuroendocrine). The seventh dynamic is an integrative dynamic that addresses the sensitivities and vulnerabilities that are observed in the six functional dynamics and a plan is then generated. You can learn more about these dynamics www.healthcoach7.com
Intelligent programing requires attention to vital process of human cells and systems working together to maintain the health of the entire organism. Beta testing and test-driving are not options in intelligent programing of human epigenetics. This intelligence architecture must be perfected as more data becomes applicable to the entire genome. We can only work with what we know currently. To put this into perspective, 23andMe is analyzing 1 million of the 15 million snp’s. The functional integration is in infancy and will grow into precise pathway analysis revealing demonstrable effects upon gene / snp expression and functional relationship.
The Common Problem
After evaluating many gene / snp profiles I have observed some commonalities. I have listed below the most crucial factors that impact health and epigenetic programming.
- Protecting healthy DNA (Methylation disturbances)
- Inhibited cellular energetics (metabolism and mitochondrial function)
- Deprivation of nutrition leading macro and micronutrient depletion
- Exposure to toxic agents and decreased ability to detoxify
- Innate immune defense slow to respond or under extreme stress
- Increased vulnerability for autoimmune reactions
- Increased vulnerability for prolonged inflammation
- Enzyme deficiencies that impair digestion, balanced metabolism and cell protection
- Cardio-methylation protection and lipid metabolism disturbances
- Body clock, stress maladaptation and neurotransmitter disturbance
- Reduced protection of the brain and CNS leading to neurodegenerative change
- Mood fluctuations caused by neuroendocrine shifts
These are some of the crucial factors that have adverse influence on epigenetics and cause unfavorable or “bad” mutations. Bad mutations are not necessarily in the form of SNP’s (Single Nucleotide Polymorphisms). SNP’s, as I discuss below, may not have any associated negativity and may demonstrate aspects of favorable adaptation. Uncorrected factors like above will increase bad signaling and harm DNA.
Preventing Bad Mutations!!!
We speak of SNPs (Single Nucleotide Polymorphisms), also known as, “tags,” “typo’s,” or ” “flips.” These mutations are usually harmless and not of any clinical significance. However, there may be indications that certain SNPs on a specified gene expose the gene to a higher percentage of risk causing an epigenetic shift to harmful mutations. Not all SNPs along a gene’s path or between the gene’s path are of negative consequence. In fact, there is evidence that point in the direction of favorable activity associated with the SNP occurring for positive benefit and protective adaptation.
Firmly, protecting healthy DNA of cells is the secret to preventing epigenetic shifts that are unfavorable. Vulnerable DNA causes epigenetic stress and is the culprit leading to unfavorable mutations and initiating oncogene activation and expression. Simply, vulnerable DNA is DNA that has been hit by an adverse force, exposure, cell environment stress and / or process of aging. Vulnerable DNA can be evident at birth of a new cell line. In other words, cell progeny can have vulnerable or “bad” DNA from the start. Often, these cells that express “bad,” DNA are labeled with antigens that demonstrate movement toward altered cell expressions that can initiate disease and premature aging. Cells that have vulnerable or “bad” DNA are prime to cause cancerous mutations if permitted to live, replicate and expand. We know this to be found in bad cells that flood the body and attach themselves in places they don’t belong causing tumors and tumor formation or flat out destroying other healthy cells of the body.
Cell Protection Basics
When a cell is exposed to harm, vital components of the cell including the nucleus, mitochondria, endoplasmic reticulum, Golgi and cell membrane are stressed. The nucleus is the command center, the mitochondria is the power house, the endoplasmic reticulum is the factory for protein manufacturing directed by the nucleus and powered by the mitochondria, the Golgi is the shipping and distribution center. DNA is the foundation of it all. Bad DNA! Bad Cell!, BAD Proteins!, Bad Shipping and Distribution!, No Protection!, Faulty and Disastrous Function! Bad Offspring! I’m sure you get the picture. Human chromosomes house all of the genes. Chromosomes can undergo remodeling that is either favorable or unfavorable. The process of this remodeling is known as telomere maintenance. Telomeres can either elongate or can become stunted. The process is directed by DNA sequencing.
Cancer Cells, DNA and Telomeres
Altered DNA sequencing leads to cancer mutations. Cancer cells reproduce at a furious pace. Telomere maintenance is the process by which they do this, they quickly reach the ends of their telomeric “ropes,” and need to find a way to lengthen them again in order to keep going. Successful cancer cells are the ones that have evolved mutations that exploit one of the cell’s two systems for renewing telomeres: either a primary system called telomerase, or in a few cases an “alternative” system appropriately called Alternative Lengthening of Telomeres (ALT). If a nascent cancer can’t find a way to seize hold of the telomerase-lengthening machinery, their telomeres will run down, their chromosomes will fray, and the cell will be destroyed before it can kill us.
Bottom Line Protect Healthy DNA!
Bad Mutations are caused by Bad DNA that initiates Bad epigenetic signaling. As mentioned above, there are some very basic ways to protect. The wisdom of genetics is in applying knowledge directly as it relates to functional health and getting results. Knowing personalized genetics is the starting place; the wisdom of personalized genetics is in its direct application. Otherwise, it’s just another field of information with no practical value! Protect your healthy DNA! Minimize harmful exposures, be sure to nurture the body with protective foods and nutrients, encourage healthy biochemistry, minimize unhealthy progressive aging by identifying key inherent gene sensitivities and vulnerabilities, thus the value of 23andMe and HealthCoach7 implementation of translating genetics in terms of functional health. These are powerful tools to influence your epigenetics in a powerful effective strategy for healthy longevity!
Basics on DNA Methylation Hypomethylation and Hypermethylation
In previous articles, we discussed the methylation process of DNA. Simply, methylation is the mechanism by which DNA is in homeostasis (healthy sequencing) or in harmful dysfunctional sequencing. Hypomethylation (decreased or low) and Hypermethylation (increased or high) are the two extremes that initiate harmful consequences upon DNA and ultimately lead to and result in unfavorable conditions and change in DNA sequencing performance. Ultimately, this leads to unfavorable function and potentially bad signals altering cell health and survival, predisposing new cell lines to “bad” mutations.
DNA methylation patterns undergo complex changes in cancer. The total amount of methylated cytosine is usually decreased resulting in global (extensive) hypomethylation. Decreased cytosine methylation typically affects satellite DNA, repetitive sequences, and CpG sites. In genetics, CpG is a site where cytosine (C) lies next to guanine (G) in the DNA sequence. (The p indicates that C and G are connected by a phosphodiester bond.) Methylation of DNA occurs at any CpG site. The cause of reduced amount of methylcytosine observed in human tumors has not been determined and remains under investigation. Despite global hypomethylation, high activity of DNA methyltransferases has been detected in multiple human tumor types. This increase may be related to higher proliferation rate of malignant cells.
Besides global (extensive) hypomethylation, most cancers also show focal hypermethylation in distinct subsets of promoter-associated CpG islands as well. Affected genes are permanently silenced, since methylation marks are propagated through mitosis and are maintained in the malignant clone. Aberrant (diverging from normal) hypermethylation occurring in transformed cells serves as an alternative mechanism for inactivation of tumor suppressor genes. Hundreds to thousands of genes can be epigenetically silenced by CpG island hypermethylation in human cancer suggesting a general disturbance of epigenetic memory. Methylation affects individual cancer patients with varying extent. While some patients have minimal changes, others show concordant hypermethylation of multiple genes. This phenomenon was first described as CpG island methylator phenotype (CIMP) in colorectal cancer and confirmed in many other types of cancer and leukemia. Epigenetic DNA methylation changes in cancer appear to be considerably more frequent events than genetic mutations. Mass sequencing of more than 20,000 transcripts in breast and colorectal cancers revealed about 80 harmless and less than 15 potentially oncogenic mutations per tumor. Balanced methylation and protective epigenetics are essential in minimizing cancer-causing mutations.
Seven Positive Changes That Create Good Epigenetic Signals
As mentioned above the twelve common areas observed initiating unfavorable epigenetic signals and leading to “bad” mutations need some positive corrections in order to prevent this occurrence.
- Identify Exposure and Adverse Toxic Conditions
- Identify Human Virobiota and Microbiota Disturbances and Immune Stress Evaluation
- Enhance Cell Metabolism, Detoxification and Mitochondria Performance
- Assess and Correct Enzyme and Nutrition Deficiencies
- Assess and Correct Target Hormones and Neuroendocrine Disturbances
- Assess and Correct Maladaptive Stress
- Assess and Correct Methylation Disturbance
- Identifying exposure and adverse toxic conditions are essential in reducing antigenic overload that creates both disturbances in the detoxification pathways, immune response and control of inflammatory pathways. For example evaluating food sensitivity testing, toxic environmental and heavy metal exposure, cross-reacting antigen analysis, are all important to reduce exposure load. There are many labs that specialize in this type of assessment. Stress, hormones, toxic metals, food antigens, environmental antigens as outlined below leave the immune defense system overloaded and contribute to negative epigenetic signaling, autoimmunity and inflammation.
This figure demonstrates the organs and cells most vulnerable to autoimmune attack and the disorder that is caused by chronic immune stress
- Identifying human virobiota and microbiota and causes of immune stress include all microbes including viruses, fungus, bacteria and toxic metabolites associated with their activity. These can be tested by blood, urine, stool and body fluids. An example of such organisms; strept, mycoplasma, candida, EBV, CMV, HHV6, Lyme’s and other organisms associated with it. This just names a few causative agents. Also immune related antibody testing as well as functional testing of T4, T8, Natural Killer Cells (CD16, 56, 57), MAST cells and various cytokines involved in immune response and regulation may be required. Replenishing and supplying the needed nurture to the immune system to assist with corrections associated from stress caused by toxic overload, virobiota and microbiota disturbance needs to be specific. Additionally, it is important to assess gut integrity and exposure to cross reactant antigens and toxins. Significant immune disturbances and inflammation are discovered when the integrity of mucosal surfaces are compromised including gut and other defense linings of the body.
This figure demonstrates the influence of virobiota and microbiota have on immunity, digestion, brain function, heart and circulation, musculoskeletal and skin. Disturbances in this balance can lead to adverse epigenetic signaling, autoimmunity and chronic inflammatory changes that can contribute to degenerative disease, cancer and premature aging.
- Enhancing cell metabolism, detoxification and mitochondria performance may involve the use of specific nutrients. Some of these nutrients can include glutathione, CoQ10, free from amino acids, nucleic sugars, added protein support, chelating nutrients, various vitamins and trace nutrients, sodium bicarbonate, select botanicals and many others, In many cases carefully architected intravenous therapy is recommended as it is very difficult to replace by oral supplementation especially if there is gut digestion and absorption concerns.
This figure demonstrates the exposures, detoxification path and nutrients involved in elimination and protection of the body. Efficient detoxification ensures enhanced epigenetic signals involved in protective adaptation.
**Personalized genetic analysis is crucial in the development of an architected plan that focuses upon encouraging enhanced protection and adaptation by providing intelligence programming of epigenetics. Replacement plans should be carefully constructed and frequently modified to accommodate and encourage favorable epigenetic signals.
- Enzyme and nutrient deficiencies are so crucial in cell health and longevity. Deprivation of key enzyme and nutrient activity can alter cell performance and predispose to premature aging, which results from DNA damage. A large number of enzymes that are involved in the digestion (amylase, lipase, sucrose, protease, etc.) and metabolism, fatty acid metabolism, mitochondrial energy regulation, cell membrane integrity, pro-oxidant and antioxidant protection, etc. An example of such enzymes are SOD (super oxide dismutase), NADH Dehydrogenase, NOS (nitric oxide synthase), COX (cyclo-oxygenases), LOX (lipoxygenases) and mitochondrial oxygenases. A good link for specific detail: http://omicsonline.org/scientific-reports/2167-0390-SR-413.pdf
Both of these diagrams why the need for specific replacement of antioxidant and better prooxidant defenses are crucial to cellular defenses and epigenetic signals that enhance protection.
- Target gland hormones, Neurohormones and Neurotransmitters are crucial to overall wellbeing. Chronic stress can cause both accelerated and inhibited function. A summary of the hormones and neurohormones below will assist you in the evaluation process.
- Brain: Melatonin, Dopamine, DOPAC, GABA, Serotonin, MAO, Taurine, Histamine, Glutamine, Catecholamine
- Thyroid: TSH, FT4, FT3, rT3, Total T3 and Total T4, Anti-TPO, Anti-Globulin and Thyroid Stimulating Immunoglobulin (TSI)
- Adrenals: Cortisol, DHEA, Norepinephrine, Epinephrine, Aldosterone
- Reproduction: Estrogen, Progesterone, Testosterone and DHEA
Neurotransmitter and hormone relationships are crucial to keeping complete brain and body balance and are integrally involved in favorable epigenetics.
Histamine is involved in many interactions in many systems of the body. As you can see from above the brain and central nervous system is very sensitive to histamine and many symptoms are associated with it.
- Maladaptive stress is a huge concern, as many people do not really know how much of a stress load their body systems are experiencing. When evaluating genetic patterns there is consistency in chronic maladaptive stress with accelerated aging, sleep disturbances, mood disorders, degenerative disease and cancer. Many of the circadian regulatory gene / snp combinations on the monographs in Genecards (www.genecards.org) demonstrate association with unfavorable health changes. Epigenetic signals that are unfavorable lean toward bad mutations resulting in poor adaptation can decrease longevity and health. Chronic stress and need for rebalancing adaptation calls for intravenous nutritional replacement. A complete hormonal and neurohormonal assessment is also recommended.
Check this link for the NEI Gold Analysis: https://www.neurorelief.com/index.php?p=testing
- Correcting methylation disturbance is important in overall protective epigenetics. However, it should not be the beginning point. The preceding actions mentioned above as they are addressed will begin with the adaptation process and will influence methylation activity. However, methylation disturbance does need to be addressed. Some of the familiar names that you may recognize are methyl donors (methyl B12, adenoB12, etc.) MTHF, NAC, SAMe, methionine, molybdenum, selenium, CoQ10, riboflavin, thiamine, biotin, niacin and many more. Before attempting balancing out the methylation cycle it is essential to know your foundational genetics and have it analyzed by www.healthcoach7.com. Identifying key aggravating factors as mentioned above is essential. Quick and short term is not the best approach here. There are no simple answers and epigenetic influence is a lifelong process to keep healthy. The methylation cycle is not simple and has many arms. Powering up your genetics and changing unfavorable epigenetics requires specific focus and plan.
Methylation is not a simple process it is set by your genetics and epigenetics!
This article has covered a vast amount of information that will assist you in being able to assist in triaging a personalized plan that is direct, specific and comprehensive. With increasing knowledge in genetics and epigenetics there will be more precise monitoring and solutions in the future. This is the most powerful direction in health and wellness an individual can pursue. Personalized genetics and epigenetics are not a thing of the future it is now. I have worked numerous individuals that have noticed profound differences in approaching and addressing their health concerns. Generating a specific life plan in personalized epigenetics is an investment that will transcend. Health and longevity will be yours as the greatest investment return for generations to come!
Dr. John Catanzaro’s favorite nutrients for this article.
THIS BLOG claims no credit for any images posted on this site unless otherwise noted. Images on this blog are copyright to its respectful owners. If there is an image appearing on this blog that belongs to you and do not wish for it appear on this site, please E-mail with a link to said image and it will be promptly removed.